Increasing territorial capitalization by incorporation of small enterprises into clusters

Modernization of the Russian national economy depends on small businesses and their involvement in capitalization of the territorial potential. This article discusses methods, models, and mechanisms of territorial capitalization based on incorporation of small business enterprises into clusters along with medium- and large businesses. We propose an optimization model for assessing the efficiency of such clusters: our research has shown that this model can be applied for decision-making in regional strategic planning. Methodologically, this study relies on the theories of industrial development and economic growth, the industrial cluster theory, and the works of Russian and international researchers on mechanisms of management of territorial potential, their establishment and implementation. Capitalization of the region's resource potential manifests itself in the form of static and dynamic effects. We developed models of interaction between small and other businesses and structures within a cluster oriented towards territorial capitalization. We demonstrated that incorporation of a university into a cluster structure increases the innovative capacity of all cluster members. This research may be further expanded to study the mechanisms of involving small businesses operating in peripheral areas into clusters

Control of Residual Organic Solvents in Active Substances

Depending on the class of toxicity, organic solvents used or formed during the production of active substances may pose risks to human health. Therefore, residual Depending on the class of toxicity, organic solvents used or formed during the proorganic solvents must be controlled, and limits for their content must be established. The article covers requirements and approaches to the assessment and establishment of maximum permissible quantities of residual organic solvents in active substances. This will help applicants decide on the need to either include the residual solvent control into product specification files or justify its absence in order to ensure the safety of medicines

Monte Carlo modelling of Raman scattering in a multi-layered tissue

The report is concerned to Monte Carlo modelling of Raman scattering. A model of Raman scattering in multi-layered tissues has been built. A number and optical properties of tissue layers, number of photons, geometric size of the model and parameters of the light source may be varied by users. Some of computational results have been compared with other investigators.This research was supported by the Ministry of Education and Science of the Russian Federation

Content of protein and glycoproteins, their components in the oral fluid in children with chronic gastritis, duodenitis

In the oral fl uid of children with chronic gastritis, duodenitis there is the increased protein content (up to 7.33±0.43 g/l) against the background of the decreasing level of glycoproteins (up to 0.03±0.01 mg/ml). Coeffi cient of ratio protein / glycoproteins in the oral fl uid is increased by a factor of 9510, which has shown the intensive decay of protein-carbohydrate complexes and the increasing content of the protein fragments. In the composition of glycoproteins there is the reduced amount of hexosamines (up to 0.23±0.01 mmol/l), against the background of the increasing sialic acids (up to 0.16±0.01 mmol/l) and fucose (up to 0.87±0.02 mmol/l). Coeffi cient of ratio of terminal and corpus monosaccharides in the glycoproteins of the oral fl uid in patients with chronic gastritis, duodenitis is increased by a factor of 2.41 and 3.34, as compared to the same values in the control group of children, which signifi cantly modifi es the functional properties of the protein-carbohydrate complexes

Guarantee of quality of electronic testirvaniya in the system of the additional vocational education

Today becomes urgent the creation of the information texnologies, based on the systems approach to the estimation of test tasks. For this it is expedient to develop test programs for the checking of the standard of knowledge of listeners. Undoubtedly, the automated evaluation of knowledge occupies here fundamental importance. We developed innovation approach to the form of the idea of the results of electronic testing. The special importance takes the form of the idea of the result of testing, which gives advantage during the guarantee of quality of educational services. It is shown that the test technologies increase the quality of instruction in the system of additional vocational educationСегодня становится актуальным создание информационных технологий, основанных на системном подходе к оценке тестовых заданий. Для этого целесообразно разработать тест-программы для контроля уровня знаний слушателей. Несомненно, автоматизированная оценка знаний занимает здесь первостепенное значение. Мы разработали инновационный подход к форме представления результатов электронного тестирования. Особое значение имеет вид представления результата тестирования, которое дает преимущество при обеспечении качества образовательных услуг. Показано, что тестовые технологии повышают качество обучения в системе дополнительного профессионального образовани

Вопросы дефектологического библиотековедения в научном наследии А.Е. Шапошникова

This article is devoted to the analysis of the scientific heritage of A.E. Shaposhnikov. The article analyzes the contribution of the scientist to the development of the domestic defectological library science, to the formation of the system view of rehabilitation tasks of the Russian libraries. Special attention is paid to the concept and methodological aspects of social and cultural rehabilitation of disabled readers, substantiated by the researcher.Статья посвящена анализу научного наследия А.Е. Шапошникова. Рассматривается вклад ученого в развитие отечественного дефектологического библиотековедения, в формирование системного представления о реабилитационных задачах российских библиотек. Особое внимание уделяется концепции и методическим аспектам социокультурной реабилитации читателя-инвалида, обоснованным исследователем

Фотодинамическая терапия рецидива базальноклеточного рака кожи теменной области после лучевой терапии

The results of the clinical observation of patient with recurrent basal cell skin carcinoma of the parietal region occurred in 4 years after radiation therapy are represented. The patient underwent photodynamic therapy (PDT) using photosensitizer fotoditazin at a dose of 1.0 mg/kg; the laser power density was 0.45 W/cm2 , the laser energy density – 300 J/cm2 . Tolerability of the treatment was satisfactory. One year after treatment there was a cosmetically satisfying soft normotrophic scar with no attachment to underlying tissues in the site of the treatment of basal cell carcinoma. According to cytological study tumor cells were not detected. For five-year follow-up there was no recurrence.Приведены результаты клинического наблюдения за пациенткой с рецидивом базальноклеточного рака кожи теменной области, возникшим через 4 года после курса лучевой терапии. Больной была проведена фотодинамическая терапия с фотосенсибилизатором фотодитазин в дозе 1,0 мг/кг; плотность мощности лазерного излучения составила 0,45 Вт/см2, плотность энергии лазерного излучения – 300 Дж/см2 . Переносимость лечения была удовлетворительной. Через один год на месте лечения базальноклеточного рака остался удовлетворительный в косметическом отношении мягкий нормотрофический рубец, не спаянный с окружающими тканями. При цитологическом исследовании опухолевые клетки не обнаружены. При пятилетнем наблюдении – без рецидива

Monte Carlo simulation of Raman light scattering in a human skin

The paper presents an algorithm for simulating Raman light scattering inside a human skin using the Monte Carlo method. The proposed algorithm uses the photon transport algorithm developed by L. Wang and S. Jacques as a basis and permits to model heterogeneities of various sizes and topologies caused by pathological processes. A skin optical model has been built with optical transport parameters compiled from Meglinski et al., Jacques and Raman active components of skin cancer from Xu Feng et al. As the most important model components collagen, elastin, keratin, cell nucleus, triolein, ceramide, melanin and water are chosen. Raman spectra of normal human skin, malignant melanoma and basal cell carcinoma skin cancers have been simulated. The reconstructed Raman spectra reached reasonably good match with the skin spectra measured in vivo. The possibility of using the algorithm to estimate changes in the concentration of skin components with the development of malignant neoplasm by modeling Raman spectra of normal skin and skin with the malignant neoplasm and comparing them with the corresponding experimental Raman spectra is examined.This study was supported by the RFBR Grant № 19-52-18001 Bolg_а and the Russian Federation President grant for state support of young scientists (project MK-1888.2019.2)